The Lundquist Institute receives $ 3 million from the NIH to expand the male contraception study

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Released: October 27, 2021 at 2:29 p.m. CDT|Updated: 2 hours ago

LOS ANGELES, October 27, 2021 / PRNewswire / – The Lundquist Institute announced that its male birth control study has received an additional study $ 3 million from the National Institutes of Health (NIH) to expand its work and recruit more than 120 couples. This NIH funding will bring the total number of couples involved in the study to over 400. In addition to accepting couples at Lundquist in Los Angeles, more couples are being recruited in Sacramento, California (UC Davis), Norfolk, Virginia (Eastern Virginia School of Medicine), Stockholm, Sweden (Karolinska Institute), Santiago, Chile (Shady Grove Reproductive Center) and other centers in the United States, Italy and Kenya.

The Lundquist Institute and its sister institutions were so successful in recruiting couples for this study that the NIH increased funding to allow couples currently enrolled to complete the study and to recruit more couples to complete the two-year clinical trial through 2023 To be completed The criteria for participating in the study include the following:

  • Men must be between 18 and 50 years old.
  • Women must be between 18 and 34 years old and have a regular menstrual cycle.

During the clinical trial, the man’s sperm count should be low enough in about four months to prevent pregnancy, but it can take up to six months. At this point, the couple will use the study contraceptive gel as their only form of contraception for 12 months. The man will be examined monthly during the course of the study, with the sperm count being tested and testosterone monitored at each visit. The partner is examined every three months. After 12 months, the man will stop using the contraceptive gel for the study and will continue to be observed until his sperm count returns to normal, which usually takes about four months.

“We are so incredibly honored to be part of this program, given the remarkable advances we are seeing in the prevention of pregnancy in couples,” said Dr. Christina Wang and Ronald Swerdloff, Investigators at the Lundquist Institute and professors of medicine at Geffen Medical School at UCLA. “It was amazing to watch each couple’s progress and see how month after month the majority of men are not adversely affected by using this gel as their primary method of contraception. Sperm count is incredibly low or zero – and normal sperm levels are Man is restored within a few months of stopping daily use of the gel. “

The story of a couple illustrates the need for study. Eilen and Stephen are one of 48 couples who have been in the so far Los Angeles Areas that participated in the two-year Phase 2 clinical trial. The gel formulation was developed by the Population Council and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the NIH.

Eilen had tried several contraceptives and was tired of the side effects: mood swings, weight gain, irregular periods. When she spotted an Instagram post last winter announcing the clinical trial for a new reversible contraceptive gel for men, she contacted the research team at the Lundquist Institute.

“I had to find out more and see if we qualified,” said Eilen. Fifteen months later, she and her partner Stephen participated in the male birth control clinical trial conducted at The Lundquist in. started January 2019.

“It’s been going well so far. No problems,” said Stephen, who applies a pump (about a teaspoon) of contraceptive gel to each of his shoulders at the same time each day. This is your new method of birth control. The gel contains segesterone acetate, a synthetic progestin that blocks natural testosterone production in the testicles and reduces sperm production. The gel also contains testosterone replacement to help maintain normal sex drive and other hormone-dependent functions.

For Eilen and Stephen it has been more than 15 months since he used the gel. Stephen had minor changes in libido very early on in the process that neither bothered him nor rush and were quickly corrected. He did not experience any negative side effects from the male contraceptive gel. Eilen was happy to get off the birth control roller coaster without fear of unwanted pregnancy. The new method of contraception has changed the game for them.

“We had a really great experience,” said Stephen. “Dr. Wang and the team are really supportive and patient with us in answering all of our questions. There has never been a point where we felt we had not made the right decision by participating in this study.”

Couples wishing to participate in the full two-year clinical trial can receive more information or sign up by email Michael Massone ([email protected] or visit: menshealth-lundquist.org).

Media contact for the Lundquist Institute:
Max Benavidez [email protected] 310-200-2682

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SOURCE The Lundquist Institute

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